Yes, Documents To Go can synchronize with multiple desktop computers by using the Documents To Go Desktop program, or by using an online “cloud storage” service. To add a new desktop, just go to the desktop tab and hit “Add a desktop” and on your desktop, you will need to click on “Add Device”. For instructions on how to set up a desktop computer, click here. When you sync a desktop computer, you can set files to sync with that computer. When you have multiple computers, you can add files to either computer, but not both. If the same document is added to both computers, two different copies of the file will sync with their respective desktop. If you want all of your files to sync between all of your devices, I would recommend using Docs to Go’s Cloud feature which you can read more about by clicking here.